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Interior Design Element

Faculty


Robert S. Haltiwanger, Ph.D.
Professor
Department of Biochemistry and Cell Biology

Recent Publications


  1. Luo, Y., Koles, K., Vorndam, W., Haltiwanger, R.S., and Panin, V.M. (2006) Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats. J. Biol. Chem. IN PRESS.
  2. Luo, Y., Nita-Lazar, A., and Haltiwanger, R.S. (2006) Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats. J. Biol. Chem. IN PRESS.
  3. Rampal, R., Li, A.S.Y., Moloney, M.J., Georgiou, S.A., Luther, K.B., Nita-Lazar, A., and Haltiwanger, R.S. (2005) Lunatic fringe, Manic fringe, and Radical fringe recognize similar specificity determinants in O-fucosylated EGF repeats. J. Biol. Chem. 280,  42454-42463.
  4. Rampal, R., Arboleda-Velasquez,  J.F., Nita-Lazar, A., Kosik, K.S., and Haltiwanger, R.S. (2005) Highly Conserved O-fucose sites have distinct effects on Notch1 function.  J. Biol. Chem.  280, 32133-32140.
  5. Arboleda-Velasquez,  J.F., Rampal, R.,  Fung, E.,  Darland,  D.C.,  Liu,  M.,  Martinez,  M.C.,  Donahue,  C.P.,  Navarro-Gonzalez,  M.F.,  Libby, P.,  D'Amore, P.A.,  Aikawa,  M., Haltiwanger,  R.S., Kosik, K.S. (2005) CADASIL mutations impair Notch3 glycosylation by Fringe. Hum. Mol. Genet.14, 1631-1639.
  6. Luo, Y. and Haltiwanger, R.S. (2005) O-fucosylation of Notch occurs in the endoplasmic reticulum. J. Biol. Chem. 280,11289-11294.
  7. Haltiwanger, R.S. and Lowe, J.B. (2004) Role of Glycosylation in Development. Annu. Rev. Biochem. 73, 491-537.
  8. Sturla, L., Rampal, R., Haltiwanger, R.S., Fruscione, F., Etzioni, A. and Tonetti, M. (2003) Differential terminal fucosylation of N-linked glycans versus protein O-fucosylation inLeukocyte adhesion deficiency type II (CDG IIc). J. Biol. Chem.278, 26727-26733.
  9. Shao, L., Moloney, D.J., and Haltiwanger, R.S. (2003) Fringe modifies O-fucose on mouse Notch1 at EGF repeats within the ligand-binding site and the Abruptex region. J. Biol. Chem. 278, 7775-7782.
  10. Haltiwanger, R.S. (2002) Regulation of signal transduction pathways in development by glycosylation. Current Opin. Struc. Biol. 12, 593-598.
  11. Haltiwanger, R.S. and Stanley, P.S. (2002) Modulation of receptor signaling by glycosylation: Fringe is an O-fucose-ß1,3-N-acetylglucosaminyltransferase. Biochem. Biophys. Acta. 1573, 328-335.
  12. Shao, L., Luo, Y., Moloney, D.J. and Haltiwanger, R.S. (2002) O-Glycosylation of EGF Repeats: Identification and Initial Characterization of a UDP-Glucose: Protein O-Glucosyltransferase. Glycobiology 12, 763-770.
  13. Panin, V.M., Shao, L., Lei, L., Moloney, D.J., Irvine, K.D. and Haltiwanger, R.S. Notch ligands are substrates for EGF protein O-fucosyltransferase and Fringe. (2002) J.Biol. Chem. 277, 29945-29952.
  14. Yan, Y.-T., Liu, J.-J., Luo, Y., E, C., Haltiwanger, R.S., Abate-Shen, C. and Shen, M.M. (2002) Dual roles of Cripto as a ligand and co-receptor in the Nodal signaling pathway. Mol. Cell. Biol. 22, 4439-4449.
  15. Wang, Y., Shao, L., Shi, S., Harris, R.J., Spellman, M.W., Stanley, P. and Haltiwanger, R.S. (2001) Modification of Epidermal Growth Factor-Like Repeats with O-Fucose: Molecular Cloning and Expression of a Novel GDP-Fucose: Polypeptide O-Fucosyltransferase. J. Biol. Chem. 276, 40338-40345.
  16. Haltiwanger, R.S. (2001) Fringe: A glycosyltransferase that modulates Notch signaling. TIGG 13, 157-165.
  17. Moloney, D.J., Panin, V.M., Johnston, S.J., Chen, J., Shao, L., Wilson, R., Wang, Y., Stanley, P., Irvine, K.D., Haltiwanger, R.S. and Vogt, T.F. (2000) Fringe is a Glycosyltransferase that Modifies Notch. Nature 406, 369-375.
  18. Moloney, D., Shair, L.H., Lu, F., Xia, J., Locke, R., Matta, K.L. and Haltiwanger, R.S. (2000) Mammalian Notch 1 is modified with two unusual forms of O-linked glycosylation found on Epidermal Growth Factor-like modules. J. Biol. Chem. 275, 9604-9611.
  19. Moloney, D. and Haltiwanger, R.S. (1999) The O-linked fucose glycosylation pathway: Identification and characterization of a UDP-glucose: O-fucose b1,3glucosyltransferase. Glycobiology 9, 679-687.
  20. Moloney, D.J., Lin, A.I., and Haltiwanger, R.S. (1997) The O-Linked Fucose Glycosylation Pathway:; Evidence for Protein-Specific Elongation of O-Linked Fucose in Chinese Hamster Ovary Cells. J. Biol. Chem. 272, 19046-19050.


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