|
|
 |
|
|
 |
|
|
Robert S. Haltiwanger, Ph.D.
Professor
Department of Biochemistry and Cell Biology
Recent
Publications
|
- Luo, Y., Koles, K., Vorndam, W., Haltiwanger, R.S., and Panin, V.M. (2006)
Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats. J.
Biol. Chem. IN
PRESS.
- Luo, Y., Nita-Lazar, A., and Haltiwanger, R.S. (2006) Two distinct pathways
for O-fucosylation of epidermal growth factor-like or thrombospondin type 1
repeats. J.
Biol. Chem. IN
PRESS.
- Rampal, R., Li, A.S.Y., Moloney, M.J., Georgiou, S.A., Luther, K.B., Nita-Lazar,
A., and Haltiwanger, R.S. (2005) Lunatic fringe, Manic fringe, and Radical
fringe recognize similar specificity determinants in O-fucosylated EGF repeats. J.
Biol. Chem. 280, 42454-42463.
- Rampal, R., Arboleda-Velasquez, J.F., Nita-Lazar, A., Kosik, K.S.,
and Haltiwanger, R.S. (2005) Highly Conserved O-fucose sites have distinct
effects on Notch1 function. J.
Biol. Chem. 280, 32133-32140.
- Arboleda-Velasquez, J.F., Rampal, R., Fung, E., Darland, D.C., Liu, M., Martinez, M.C., Donahue, C.P., Navarro-Gonzalez, M.F., Libby,
P., D'Amore, P.A., Aikawa, M., Haltiwanger, R.S.,
Kosik, K.S. (2005) CADASIL mutations impair Notch3 glycosylation by Fringe. Hum.
Mol. Genet.14,
1631-1639.
- Luo, Y. and Haltiwanger, R.S. (2005) O-fucosylation of Notch occurs in the
endoplasmic reticulum. J.
Biol. Chem. 280,11289-11294.
- Haltiwanger, R.S. and Lowe, J.B. (2004) Role of Glycosylation in Development. Annu.
Rev. Biochem. 73,
491-537.
- Sturla, L., Rampal, R., Haltiwanger, R.S., Fruscione, F., Etzioni, A. and
Tonetti, M. (2003) Differential terminal fucosylation of N-linked
glycans versus protein O-fucosylation inLeukocyte
adhesion deficiency type II (CDG IIc). J.
Biol. Chem.278,
26727-26733.
- Shao, L., Moloney, D.J., and Haltiwanger, R.S. (2003) Fringe modifies O-fucose
on mouse Notch1 at EGF repeats within the ligand-binding site and the Abruptex
region. J.
Biol. Chem. 278,
7775-7782.
- Haltiwanger, R.S. (2002) Regulation of signal transduction pathways in
development by glycosylation. Current
Opin. Struc. Biol. 12,
593-598.
- Haltiwanger, R.S. and Stanley, P.S. (2002) Modulation of receptor signaling
by glycosylation: Fringe is an O-fucose-ß1,3-N-acetylglucosaminyltransferase. Biochem.
Biophys. Acta. 1573,
328-335.
- Shao, L., Luo, Y., Moloney, D.J. and Haltiwanger, R.S. (2002) O-Glycosylation
of EGF Repeats: Identification and Initial Characterization
of a UDP-Glucose: Protein O-Glucosyltransferase. Glycobiology 12,
763-770.
- Panin, V.M., Shao, L., Lei, L., Moloney, D.J., Irvine, K.D. and Haltiwanger,
R.S. Notch ligands are substrates for EGF protein O-fucosyltransferase
and Fringe. (2002) J.Biol.
Chem. 277,
29945-29952.
- Yan, Y.-T., Liu, J.-J., Luo, Y., E, C., Haltiwanger, R.S., Abate-Shen, C.
and Shen, M.M. (2002) Dual roles of Cripto as a ligand and co-receptor in the
Nodal signaling pathway. Mol.
Cell. Biol. 22,
4439-4449.
- Wang, Y., Shao, L., Shi, S., Harris, R.J., Spellman, M.W., Stanley, P.
and Haltiwanger, R.S. (2001) Modification of Epidermal Growth Factor-Like
Repeats with O-Fucose: Molecular Cloning and Expression of a Novel GDP-Fucose:
Polypeptide O-Fucosyltransferase. J.
Biol. Chem. 276, 40338-40345.
- Haltiwanger, R.S. (2001) Fringe: A glycosyltransferase that modulates Notch
signaling. TIGG 13,
157-165.
- Moloney, D.J., Panin, V.M., Johnston, S.J., Chen, J., Shao, L., Wilson,
R., Wang, Y., Stanley, P., Irvine, K.D., Haltiwanger, R.S. and Vogt, T.F.
(2000) Fringe is a Glycosyltransferase that Modifies Notch. Nature 406,
369-375.
- Moloney, D., Shair, L.H., Lu, F., Xia, J., Locke, R., Matta, K.L. and
Haltiwanger, R.S. (2000) Mammalian Notch 1 is modified with two unusual forms
of O-linked glycosylation found on Epidermal Growth Factor-like modules. J.
Biol. Chem. 275, 9604-9611.
- Moloney, D. and Haltiwanger, R.S. (1999) The O-linked fucose glycosylation
pathway: Identification and characterization of a UDP-glucose:
O-fucose b1,3glucosyltransferase. Glycobiology 9,
679-687.
- Moloney, D.J., Lin, A.I., and Haltiwanger, R.S. (1997) The O-Linked Fucose
Glycosylation Pathway:; Evidence for Protein-Specific
Elongation of O-Linked Fucose in Chinese Hamster Ovary Cells. J.
Biol. Chem. 272, 19046-19050.
Top of Page
|
|
|
|
|
|