Kenneth B. Marcu, Ph.D. Professor Department of Biochemistry and Cell Biology, Microbiology & Pathology Stony Brook University Adjunct Professor and Senior Research Scholar CRBA Laboratory S. Orsola University Hospital University of Bologna (UNIBO) Bologna, Italy USA Contact Information: Biochemistry and Cell Biology Department 330 and 326 Life Sciences Building Stony Brook University Stony Brook, NY 11794-5215 Lab telephone: 631-632-8553 Fax: 631-632-9730 E-mail: kenneth.marcu@stonybrook.edu
Research Description

We have research projects on-going concurrently in the United States and in Europe. Besides my research group here at the Biochemistry and Cell Biology Dept. SUNY Stony Brook, I have another research group at the Centro Ricerca Biomedica Applicata, S. Orsola Univ. Hospital of the University of Bologna ( Italy). Our current projects (ca. January 2007) include: (1) The regulation and mechanisms of action of the inhibitor of NF-kappaB kinase (IKK) complex, which is essential for the activation of the NF-kappaB transcription factor family (pivotal regulators of stress-like responses, innate and adaptive immunity and the survival and growth of normal and malignant cells). Here we are employing different biological systems in a variety of in vitro and in vivo settings (including innate immune responses in disease states and regulatory changes converting normal cells into neoplastic ones). The focus of our research is in part to elucidate novel mechanism(s) of action of IKKalpha and how they overlap or differ with those of its NF-kappaB activating partner kinase IKKbeta and (2) The molecular basis of immunoglobulin heavy chain (Igh) class switch recombination (CSR) in adaptive immune responses. Here our research interests are focused on an inducible proteomics approach to define the mechanisms of action of the 'Activated Induced Deaminase' (AID) protein in CSR.

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