Rolf Sternglanz Distinguished Professor Department of Biochemistry and Cell Biology Life Sciences Building Stony Brook University Stony Brook, NY 11794-5215 Office telephone: 631-632-8565 Fax: 631-632-9730 E-mail: rolf@life.bio.sunysb.edu
Research Description

Our lab uses the budding yeast, Saccharomyces cerevisiae to identify mutants and characterize genes affecting structure and function of the nucleus. This includes genes encoding proteins involved in gene regulation, DNA replication or chromatin structure. Current effort is focused on: 1) the mechanism of transcriptional silencing of the mating-type loci (i.e., a study of the yeast equivalent of heterochromatin), 2) identification of genes encoding histone acetyltransferases, deacetylases and other histone modifying enzymes, and 3) the role of the nuclear periphery in regulation of DNA replication and silencing.

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